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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T11829 | LDH-IN-1 | Dehydrogenase | |
LDH-IN-1 is a pyrazole-based human lactate dehydrogenase (LDH) inhibitor(IC50s of 32 and 27 nM for LDHA and LDHB, respectively). | |||
T12438 | PfDHODH-IN-1 | Dehydrogenase , Parasite | |
PfDHODH-IN-1 is an analogue of the active Leflunomide metabolite, has antimalarial activity. | |||
T11546 | HDHODH-IN-1 | Dehydrogenase | |
hDHODH-IN-1 is a human dihydroorotate dehydrogenase (hDHODH) inhibitor with an anti-inflammatory effect. | |||
T77579 | JC2-11 | IL Receptor , Dehydrogenase , ROS , Caspase , NOD-like Receptor (NLR) , AIM2 | |
JC2-11 is an inhibitory compound for inflammation.JC2-11 inhibits the recruitment domain-containing proteins NLRC 4, atypical in melanoma 2 (AIM 2) and atypical (NC) inflammatory vesicles by disrupting reactive oxygen sp... | |||
T4S0779 | D-tetrahydropalmatine | Others , Dopamine Receptor | |
D-Tetrahydropalmatine is a organic cation transporter 1 (OCT1) inhibitor, it can obviously inhibit the uptake of monocrotaline (MCT) in MDCK-hOCT1 cells and isolate rat primary hepatocytes, and attenuate the viability re... | |||
T5S0106 | Peimisine | Ebeiensine | RAAS , AChR |
1. Peimisine (Ebeiensine) can affect M-receptor, excit β-receptor, restrain the release of internal calcium, and promote to releaseing nitrogen monoxidum in order to relax tracheal smooth muscle and relieve asthma. 2. Pe... | |||
T70032 | NCI-006 | ||
NCI-006 is a potent new inhibitor of lactate dehydrogenase (LDH) that disrupts tumor growth in mice. LDH inhibition slows tumor growth but rapidly redirects pyruvate to support mitochondrial metabolism. Inhibiting both m... | |||
T76146 | D-Lactate dehydrogenase | ||
D-Lactate dehydrogenase (D-LDH), an oxidoreductase, catalyzes the oxidation of D-lactate to pyruvate leveraging NAD+ or NADP+ as acceptors and acting on the donor CH-OH group. Predominantly found in bacteria and fungi, i... | |||
T36498 | CAY10762 | CAY10762 | |
CAY10762 is an inhibitor of monoacylglycerol lipase (MAGL; IC50= 34.1 nM).1It reduces hydrogen peroxide-induced lactate dehydrogenase (LDH) release from Neuro2a cells when used at a concentration of 1 μM. CAY10762 (10 mg... | |||
T61312 | Antioxidant agent-3 | ||
Antioxidant agent-3 (Compound 14q), a potent antioxidant, exhibits strong scavenging activity against DPPH radicals and ABTS+ radicals, with IC50 values of 26.58 μM and 30.31 μM, respectively. Additionally, it enhances t... | |||
T81747 | MS6105 | PROTACs | |
MS6105 is a chimeric LDH protein hydrolysis-targeted PROTAC that degrades LDHA and LDHB efficiently, with its activity contingent on both time and the ubiquitin-proteasome system, exhibiting anticancer properties [1]. Ad... | |||
T83768 | Zofenoprilat | Zofenopril-SH,SQ 26,333 | |
Zofenoprilat, an angiotensin-converting enzyme (ACE; IC50 = 8 nM for rabbit lung enzyme) inhibitor and the active metabolite of the prodrug zofenopril, effectively counters angiotensin I- or bradykinin-induced contractio... |